The Croatian Chamber of Commerce has been continuing the tradition since 1997 of conducting the “Let’s buy Croatian” campaign, and this year through the specialized project “Let’s buy Croatian – Croatian products for Croatian tourism”. The project will take place on April 20 and 21, 2016 on 2.500 square meters in the Žatika sports hall in Poreč.In the fair atmosphere, domestic producers will present their products and services through several thematic areas defined according to the needs of hotels, caterers and other providers of accommodation and other services in tourism.Objectives of the project “Buy Croatian – Croatian products for Croatian tourism” through direct networking of producers and end customers – service providers in tourism, through an exhibition of Croatian products in the fair atmosphere and through B2B meetings identifying obstacles and finding solutions for better cooperation between domestic producers and service providers tourism, through panels and presentations and educating the youngest generations and citizens about the existence of quality Croatian products: Encourage better cooperation and better placement of domestic products on the domestic market Influence the competitiveness of the Croatian economy Influence tourism to become the bearer of Croatian identity through the offer of Croatian products Preserve existing and create new jobs Promote quality domestic products, bearers of the signs Original Croatian and Croatian qualityThe official opening will be on Wednesday, April 20, 2016, while for citizens and group school visits, the doors will open on the second day, April 21, 2016 at 10 a.m. On this occasion, visitors will be able to see the exhibited Croatian products, touch, taste, but also buy and listen to numerous promotional and educational presentations, while admission is free.You can apply for participation in the status of exhibitors until April 10, 2016, and all details and accompanying documents for exhibitors can be viewed hereSource: HGK
The Tourist Board of the City of Dubrovnik continues this year with free winter programs for tourists staying in Dubrovnik during the winter months, with the aim of encouraging tourist visits during the winter.Tako će se i ove zime, svake subote, počevši od 5. studenog 2016. pa sve do ožujka 2017. godine za goste grada organizirati besplatni razgled stare gradske jezgre s vodičem na engleskom jeziku, s početkom u 10 sati ispred TIC-a Pile, Brsalje 5. Za besplatni obilazak potrebno se prijaviti dan ranije (petak) do 18 sati u TIC Pile (tel: +38520312011; E-mail: [email protected]), and the offer is intended for individual visitors and does not apply to group arrangements. After a tour of the city with an expert guide, at 11.30 am there will be a free performance by FA Linđa in front of the church of St. Blaise, and in case of rain the performance will not take place.This free program will be a great addition to the abundance of various entertainment programs within the Dubrovnik Winter Festival in Dubrovnik, say the Tourist Board of the City of Dubrovnik.
From June 23 to September 16, Poreč is once again becoming a big open-air stage with the longest and most meaningful domestic festival – Poreč Open Air.After the successful first edition of the festival, which was visited by more than 50.000 domestic and foreign guests last year, the leading tourist company Valamar Riviera in cooperation with sponsors hosted the city of Porec and the Tourist Board of Porec and MPG, organizer of the festival on the streets and squares of Porec and the island Sveti Nikola, brings over a hundred attractive events that will make Poreč an unavoidable destination of top entertainment this summer as well. In a colorful program that includes, among other things live musical evenings, movie screenings under the stars, street performances and theater performances, visitors of all ages and tastes will have the opportunity to enjoy for free.”As the leading tourist company in the country, it is our responsibility to develop the destinations in which we operate and to be a key stakeholder in creating their content. It is the facilities that strengthen the competitiveness of the destination and enrich our guests’ vacation with unforgettable moments. Poreč Open Air is a very good example of such content, which is confirmed by the results of the festival as well as the excellent reactions of our guests returning to the destination. This year’s edition of the festival continues with daily entertainment and a diverse program for all ages, and we have improved many program concepts and are expanding this format to other destinations. ” points out Davor Brenko, Vice President of Sales and Marketing of Valamar Riviera.The successful concept of the Poreč Open Air Festival and its significance for the destination was confirmed by Loris Peršurić, Deputy Mayor of the City of Poreč – Parenzo “Poreč has always been a leader in trends in Croatian tourism, and the Poreč Open Air Festival is another proof that our city is constantly working to improve the city’s image through excellent cooperation between the public and private sectors. In addition, the Festival is held in the old town – for film screenings, music and outdoor performances, alleys and squares are used, which come to life in a completely new light. In order to revitalize the old town, just such a way of recognizing the value of our beautiful city is the direction in which we should move, so that our potentials are fully exploited. I believe that this year’s edition of the Festival, whose program is even richer than last year, will gather a large number of fans in Poreč for a good and quality pastime, and that the Poreč Open Air Festival will move forward and become a traditional event that we will always support. “Last year’s success and popularity of the Poreč Open Air Festival is proven by the large number of visitors, who were more than 20 at 50 different festival locations. In more than 000 days of the festival in 100, there were 2016 events and 251 performers, and more than 250 fans. Facebook followed the news and program of the Poreč Open Air Festival on a daily basis. It is precisely the various events combined with the natural and cultural beauties that the city abounds in, the reasons why Poreč was named the best destination for summer vacation tourism in 7.000, and the Poreč Open Air Festival won the prestigious award of the Istrian Tourist Board Golden Goat (Capra d ‘Oro) in the festivals category.Nenad Velenik, director of the Tourist Board of the City of Poreč, concluded that the Poreč Open Air Festival is a key factor in the promotion of Poreč as an exceptional tourist destination “Poreč is a destination that has recognized the positive effect of attracting new guests by organizing large festivals. In its first year, the Poreč Open Air Festival proved to be the leading content for entertaining guests in the destination, and presented our destination as a place of top experience. We are looking forward to hosting the Festival again and to providing many guests of Poreč with additional value and motivation to return to us. The slogan of our visual identity You complete us just confirms the synergy of all participants in tourism to provide our guests with unforgettable moments in Porec. “The program of this central summer event in Poreč will be updated in the coming months, and all information and news can be found at www.porecopenair.com.
Share LinkedIn Macrophages are cellular sentinels in the body, assigned to identify “attacks” from viruses, bacteria, or fungi and sound the alarm when they are present. However, these cells are a “double edged sword” in spinal cord injury, providing both neural repair-promoting properties and pathological functions that destroy neuronal tissue“We know from previous research that macrophages are versatile, and signals at the injury site can stimulate repair or destruction–or confusingly, both,” said John Gensel Ph.D., Assistant Professor of Physiology in the Spinal Cord and Brain Injury Research Center at the University of Kentucky. “But the mechanisms through which these signals stimulate the good and/or bad functions in macrophages are not known. So the next big question to answer in the efforts to understand and treat SCI was, ‘Why?’”Gensel teamed up with Phillip Popovich, Ph.D, Professor in the Department of Neuroscience and Director of the Center for Brain and Spinal Cord Repair (CBSCR) at The Ohio State University to explore the mechanisms governing the positive and negative processes that occur in macrophages following spinal cord injury. Share on Twitter Share on Facebook Pinterest “On the cellular level, the body’s response to spinal cord injury is similar to the immune response to attacks by bacteria or viruses,” Gensel said. “The functions that macrophages adopt in response to these stimuli were the focus of our study.”Gensel and Popovich looked at more than 50 animals with spinal cord injury to try to identify which macrophage receptors promoted neuronal repair and which directed the destructive process.“We found that activating bacterial receptors boosted the macrophage response and limited damage to the spinal cord following injury, while activating fungal receptors actually contributed to pathology,” Gensel said.While this study oversimplifies the complex process by which macrophages promote repair and destruction of neuronal tissues, it nonetheless sheds light on opportunities to modulate macrophage responses after spinal cord injury, potentially reducing – or even reversing – damage and the resulting side-effects.“The implications are exciting: we now can look for treatments targeted to the receptors that jump-start the macrophage’s restorative effects without activating the receptors that modulate the destructive processes in that same cell.”The study has been published as a Featured Article in the most recent issue of the Journal of Neuroscience. Email
“We were not able to investigate the specific mechanisms by which multimorbidity contributes to cognitive impairment; however our findings are consistent with the hypothesis that multiple etiologies may contribute to late-life cognitive decline and thus emphasize the importance of prevention,” said Dr. Rosebud Roberts, senior author of the Journal of the American Geriatrics Society study. “They also emphasize that chronic diseases, once diagnosed, should be efficiently managed.” Share Email In a new study of older adults, having multiple chronic conditions was linked with an increased risk of mild cognitive impairment (MCI) or dementia.Investigators assessed 2176 cognitively normal participants who were an average age of 78.5 years and were followed for a median of 4 years. Participants with more than 1 chronic condition were 38% more likely to develop MCI/dementia. Participants with 4 or more conditions had a 61% increased risk compared with those with 0 or 1 condition. Men also had a higher risk than women.The findings suggest that preventing chronic diseases may help aging adults maintain their mental health. LinkedIn Share on Twitter Pinterest Share on Facebook
LinkedIn Email Share on Twitter Share Pinterest Share on Facebook People with post-traumatic stress disorder (PTSD) have reduced activity of the protein serum and glucocorticoid regulated kinase 1 (SGK1) in their prefrontal cortices, and experimentally reducing the protein’s activity in rats leads to PTSD-like behavior, according to a new study in PLOS Biology.The study by Pawel Licznerski, Ronald Duman and colleagues of the Department of Psychiatry at Yale University publishing in the Open Access journal PLOS Biology on Oct. 27th, suggests that augmenting activity of SGK1 may be therapeutic in PTSD.Performing a whole-genome expression screen on the post-mortem brains of six subjects with PTSD, the authors found that expression of SGK1 was reduced in the prefrontal cortex by over 80% compared to controls. The subjects studied were part of a PTSD brain bank, the first of its kind, established by the authors. To understand the cellular mechanisms at work, the authors turned to rats, and showed that those rats with lower SGK1 activity had higher levels of learned helplessness in response to a shock (a behavior thought to mimic one aspect of PTSD). Experimentally reducing SGK1 activity in rats induced learned helplessness, while overexpressing the protein reduced it. Reducing SGK1 activity also induced several other PTSD-like behaviors, and caused cellular changes in prefrontal cortical neurons consistent with an augmented fear response.Together, these results indicate that a reduction in SGK1 activity likely contributes to PTSD. Larger postmortem studies will be needed to confirm these findings, but if they are borne out, SGK1 or other proteins with which it is linked may provide new targets for medications to reverse the effects of PTSD, which, according to the Veterans Administration, affects over 5% of the United States population, and over 10% of veterans.
Share on Facebook Share on Twitter Share Email People on social media are often unsupportive of cyberbullying victims who have shared highly personal feelings, UCLA psychologists report.Compared to face-to-face situations, bystanders are even less likely to intervene with online bullying. The researchers wanted to learn why bystanders are infrequently supportive of when bullying occurs online.In a new study, the researchers created a fictitious Facebook profile of an 18-year-old named Kate, who, in response to a post, received a mean comment — “Who cares! This is why nobody likes you” — from a Facebook friend named Sarah. That comment gets six likes. LinkedIn Pinterest The study involved 118 people, ages 18 to 22, from throughout the United States, 58 percent of the participants were female, and were recruited through Amazon Mechanical Turk. They were randomly divided into four groups; each group saw Sarah’s nasty comment in response to a different Facebook post from Kate. Across the four groups, Kate’s Facebook post varied in level of personal disclosure (more or less personal) and whether it was positive or negative.Two groups saw Kate make a highly personal disclosure about a relationship. “I hate it when you miss someone like crazy and you think they might not miss you back ?” (negative) or “I love it when you like someone like crazy and you think they might like you back ?” (positive).The other two groups saw Kate make a less personal comment about the popular HBO program, “Game of Thrones.” “I hate it when a Game of Thrones episode ends and you have to wait a whole week to watch more ?” or “I love it when a Game of Thrones episode ends and you can’t wait until next week to watch more ?.”Participants then responded to questions about how much they blamed Kate for being cyberbullied, how much empathy they had for Kate and how likely they would be to support her.Although the majority of participants considered Sarah’s comment an example of cyberbullying, they varied in their responses to Kate’s being bullied depending on her original post. Regardless of whether Kate’s post was positive or negative, participants viewed Kate more negatively when she posted a highly personal disclosure.“We found that when the Facebook post is a more personal expression of the victim’s feelings, participants showed lower levels of empathy and felt Kate was more to blame for being cyberbullied,” said Hannah Schacter, a UCLA graduate student in developmental psychology, and lead author of the study, which is published in the journal Computers in Human Behavior.Participants were asked, on a scale of one to five, whether they “felt for” Kate and whether they blamed Kate for Sarah’s criticism of her. Although the differences were small (about one third of point), they showed a consistent pattern of less forgiving responses when Kate posted about her personal issues as opposed to about Game of Thrones.The authors found that victim-blaming and empathy for the victim influenced whether participants would intervene by sending a supportive message to the bullying victim (Kate), posting a supportive message, or posting that they disagree with the bully’s comment. When participants felt that Kate deserved to be bullied and felt less empathy for her, they were less likely to express support for the victim.“The emotional reactions toward Kate help explain whether online bystanders are likely to support the victim,” said Jaana Juvonen, a UCLA professor of psychology and senior author of the research.“Our study suggests oversharing of personal information leads bystanders to blame and not feel for the victim,” Schacter said.On social media websites, there appear to be unwritten rules about what is acceptable, and this study suggests that oversharing personal emotions or information violates these rules, she said.“Young people need to understand that by revealing personal issues publicly online, they may make themselves more vulnerable to attacks from those seeking to harm others,” Juvonen said.Sharing your feelings with a close friend is quite different from publicly sharing with many people who don’t know you well.However, Schacter and Juvonen emphasize that the study’s findings have important implications for changing how people react when they see online bullying. Rather than placing the burden on victims to monitor their online behavior, the authors say that more online empathy is needed. This is a challenge, they note, because bystanders do not see the anguish of victims of online bullying.“Supportive messages can make a big difference in how the victim feels,” Schacter said. Other research, she noted, shows that sharing of troubles can help strengthen friendships among students and young adults.Shayna Greenberg, a recent UCLA graduate who worked with Schacter and Juvonen on the study, is a co-author.The research was partly funded by a National Science Foundation Graduate Research Fellowship and a Sigma Xi Grant in Aid of Research for Schacter.Previous studies on bullying by Juvonen and her colleagues have found that:Bullies are considered the “cool” kids in school.Nearly three in four teenagers say they were bullied online at least once during a 12-month period.Nearly half of the sixth graders at two Los Angeles-area schools said they were bullied by classmates during a five-day period.
Pinterest Share on Facebook “Patients who experience pain and anxiety may move during the procedure, which can reduce the effectiveness of biopsy, or they may not adhere to follow-up screening and testing,” Soo said.She added that the study comes at a time when federal reimbursement requirements are increasingly focusing on patient care and adjusting payments based on patient satisfaction.“It’s important that we address these issues to provide a better experience and more compassionate care for our patients,” Soo said.Soo and colleagues enrolled 121 women undergoing breast cancer diagnosis at Duke and randomly assigned them to receive one of three approaches as they underwent stereotactic and ultrasound-guided biopsy: a recorded meditation, music, or standard care with a technologist offering casual conversation and support.The meditation was a guided “loving/kindness” script that focused on building positive emotions such as compassion towards oneself and others and releasing negative emotions.Patients in the music group listened to their choice of instrumental jazz, classical piano, harp and flute, nature sounds or world music.Standard-care patients received supportive and comforting dialogue with the radiologist or technologist.Immediately before and after biopsy, participants completed questionnaires measuring nervousness and anxiety, ranking biopsy pain between a low of zero to a high of 10, and assessing feelings of weakness and fatigue.Patients in the meditation and music groups reported significantly greater reductions in anxiety and fatigue after biopsy than those receiving standard care. The standard-care patients reported increased fatigue after biopsy.The meditation group also showed significantly lower pain during biopsy when compared to the music group.“Listening to guided meditation resulted in significantly lower biopsy pain during imaging-guided breast biopsy, and both meditation and music reduced patient anxiety and fatigue,” Soo said. “There are medical approaches to this — providing anti-anxiety drugs — but they sedate patients and require someone to drive them home.“Meditation is simple and inexpensive, and could be a good alternative in these settings,” Soo said. “We would like to see this study scaled up to include a multi-center trial, and see if the findings could be generalized to different practices.” Meditation eases anxiety, fatigue and pain for women undergoing breast cancer biopsies, according to researchers at the Duke Cancer Institute. They also found that music is effective, but to a lesser extent.The researchers note that adopting these simple, inexpensive interventions could be especially helpful in light of recent reports citing anxiety and pain as potential harms from breast cancer screenings and testing.“Image-guided needle biopsies for diagnosing breast cancer are very efficient and successful, but the anxiety and potential pain can have a negative impact on patient care,” said Mary Scott Soo, M.D., associate professor of radiology at Duke Cancer Institute and lead author of the study published online February 4 in the Journal of the American College of Radiology. LinkedIn Email Share Share on Twitter
LinkedIn Pinterest Share A Centre for Healthy Brain Ageing (CHeBA) paper published in Current Alzheimer Research presents the first detailed study of the relationship between plasma levels of two amyloid beta peptides (Aβ1-40 and Aβ1-42), brain volumetrics (measures studying the size of brain, which shrinks with Alzheimer’s disease) and cognitive performance in an investigation of the usefulness of plasma levels as a biomarker for Alzheimer’s disease (AD).Lead author on the paper and head of CHeBA’s Proteomics Group at the University of New South Wales, Dr Anne Poljak, said that since amyloid beta (Aβ) peptides are the main component of the amyloid plaques found in Alzheimer patients’ brains, changes in levels of Aβ in blood plasma may provide a biomarker for detecting increased risk or early diagnosis of disease.“While Aβ has traditionally been measured using cerebrospinal fluid, plasma presents a more accessible sample for routine collection and screening although results to date have been variable,” Dr Poljak said. Email Share on Facebook Share on Twitter The study examined age-matched cognitively normal controls (n=126), individuals with amnestic mild cognitive impairment (aMCI, n=89) from CHeBA’s Sydney Memory & Ageing Study, as well as individuals with Alzheimer’s disease (AD, n=39).Plasma levels of the two peptides and the Aβ1-42/1-40 ratio were lower in aMCI and Alzheimer’s disease than in cognitively normal controls, and lower levels of Aβ1-42 were associated with lower global cognition and hippocampal volume and higher levels of white matter hyperintensities (which are believed to contribute to Alzheimer’s disease). A genetic component was also identified, with associations between Aβ1-40 and cognitive and brain volume measures predominantly observed in individuals carrying the ε4 allele, while the opposite was observed in non-carriers. Longitudinal analysis revealed greater decline in global cognition and memory for the highest quintiles of Aβ1-42 and the ratio measure.Director of CHeBA and co-author on the paper, Professor Perminder Sachdev, said he was encouraged by the findings.“These findings certainly suggest that plasma Aβ measures may serve as biomarkers of Alzheimer’s disease,” he said.
Mansuy’s team of researchers has now demonstrated for the first time that such trauma-related behavioral alterations are reversible in mice. If male mice exposed to trauma in early postnatal life live in pleasant conditions as an adult, their behavior and the behavior of their offspring returns to normal. “Long after the traumatic experiences themselves, living in enriched conditions reverses the behavioral symptoms in adult animals and also prevents the transmission of these symptoms to the progeny”, summarizes Isabelle Mansuy the new findings.Lead author Katharina Gapp and her colleagues exposed newborn male mice to traumatic stress by separating them from their mothers at irregular intervals and stressing their mother unpredictably during separation. Subsequently, the male mice and their male offspring behaved significantly differently from the control mice when exposed to challenging situations. Examples related to their natural avoidance of bright light or their behavior when confronted with complex and constantly changing tasks, for example to obtain a water ration when thirsty.Epigenetic dysregulation of the glucocorticoid receptor gene is reversibleAt the molecular level, these behavioral alterations are associated with an increased level of the glucocorticoid receptor in the hippocampus – a brain area essential for cognitive processes and that contributes to stress responses. This altered expression results from an epigenetic dysregulation of the gene for the receptor that binds stress hormones like cortisone. The activity of this gene is normally reduced by DNA methylation, an epigenetic mark that silences genes. Traumatic experiences lead to the removal of some of these DNA methylation marks which results in an increase in gene activity and an increased production of the glucocorticoid receptor.The epigenetic alterations are not only found in the hippocampus of the offspring of traumatized mice, but also in the germ cells of their fathers. The scientists thus assume that alterations in DNA methylation are transmitted to the progeny through the sperm. Isabelle Mansuy and her team have now shown that the impact of childhood trauma can be corrected by a low-stress and enriched environment in adult life. At the same time, the correction the of DNA methylation pattern prevents the symptoms from being inherited by the offspring.A universal mechanism for transmitting characteristics caused by the environment“Until now, only pharmacological drugs were known to correct epigenetic alterations in a consequential way for behavior. Now we know that this is also possible through environmental manipulations such as enriched conditions”, highlights Isabelle Mansuy. The researchers suspect that this reversible epigenetic transmission is an universal mechanism that may also be partially responsible for transmitting other characteristics to the offspring, for example metabolic disorders due to poor nutrition or pathologies induced by endocrine disruptors. Share Traumatic experiences in childhood increase the risk of developing behavioral and psychiatric disorders later in life. It is also known that the consequences of a trauma can likewise be observed in the children of people affected even if those children have themselves not experienced any trauma. However, childhood trauma in some conditions can also help individuals deal better with difficult situations later in life. This ability, too, is passed onto following generations.These findings, published in Neuropsychopharmacology, have recently been uncovered by Isabelle Mansuy, Professor of Neuroepigenetics at the University of Zurich and ETH Zurich, during investigations carried out in mice.A positive environment reverses behavioral symptoms Email Share on Facebook Pinterest LinkedIn Share on Twitter